Human Gene Therapy

Positron emission tomography (PET) images 24 hr after administration of I-124 labeled AAVrh10 by the intracisternal route to a nonhuman primate, showing differences in organ biodistribution between serotype naïve (left) and serotype immune (right) status. With anti-capsid immunity, uptake in the spleen increased by more than a factor of 10. For details see Ballon et al., pp. 1237–1259.