Careers

  • Imagine working for a company that is working to go beyond treating the symptoms of genetic disease by trying to stop its progress at its underlying cause.
  • That’s what we do every day at Lexeo Therapeutics.
  • We’re not content to simply make better therapies – we want to change the arc of medicine. That passion drives us, and we look for it in every person we bring to our team.
  • Ready to be a part of it? See our openings below.

COMPANY BENEFITS:

Health Insurance & Wellness benefits

  • Health, dental and vision benefits
  • Flexible Spending Account (FSA)
  • Health Savings Account (HSA)
  • Disability insurance
  • Life insurance
  • Mental health benefits

Perks & Discounts

  • Commuter benefits
  • Tech stipend
  • Stocked kitchen
  • In office lunch stipend

Retirement & Stock option benefits

  • 401(K) with company match
  • Performance bonus
  • Company equity

Vacation & Time off benefits

  • Unlimited PTO
  • Paid holidays
  • Paid parental leave

Clinical Development

Director, Clinical Scientist, Gene Therapy

  • Hybrid / Full time
  • New York, New York, US
The Clinical Scientist is responsible for providing scientific input during protocol development, study design, oversight of clinical aspects of study conduct, and interpretation of study results through the final study report.  The Clinical Scientist will work closely with other clinical development and operations team members to execute and deliver milestones.  The successful candidate will be highly collaborative and motivated, with excellent knowledge of clinical trial design, preferably with experience in rare diseases and gene or cell therapy within cardiovascular disease.  The candidate must also possess excellent leadership, communication, and organizational skills, be solution-oriented, exhibit high attention to detail and quality, and have strong initiative and execution to timelines.

If you enjoy being a part of a growing team and an entrepreneurial environment in which your work will have a meaningful impact on clinical trial progress for novel gene therapies, we want to hear from you! 

Primary Responsibilities

  • Contributes to creation of clinical development strategic plan, clinical trial design, electronic case report forms (eCRFs), and statistical analysis plans
  • Preparation (or oversight of vendor preparation) of protocols and ancillary study documents, case report forms, operations manuals, investigator’s brochures, and operations manuals in collaboration with Clinical Operations Director
  • Preparation (or oversight of vendor preparation) of data table, listings, figures, clinical study reports and clinical submission documents
  • Close collaboration with clinical operations team to oversee protocol feasibility assessments, site identification, review of provider specifications, and vendor evaluation 
  • Close collaboration with clinical operations team to review relevant vendor, CRO and site scopes of work, study budgets, and plans or manuals related to study data, IVRS, central labs, etc.
  • Development of internal and external training materials and presentations 
  • Review and analysis of interim and final clinical trial data, including summarizing potential safety and efficacy trends, for study documents including CSRs, IBs, and DSURs
  • Close collaboration with clinical development lead in strategic planning and conduct of investigator meetings and advisory boards
  • Close collaboration with clinical development lead in preparation of abstracts, manuscripts, presentations, and materials for external meetings as related to the protocol and/or clinical program
  • Oversight of scientific activities outsourced to vendors and clinical research organizations 

Qualifications

  • Relevant clinical (MD) or biomedical Ph.D. preferable
  • At least 5-10 years of drug development or medical research experience within the biopharmaceutical industry; candidates with only academic experience may be considered
  • Excellent knowledge of clinical trial design, statistics, and data review tools
  • Significant experience in the development of protocols and case report forms
  • Ability to share scientific data effectively across functions and through presentations
  • Significant experience reviewing and analyzing clinical trial data to identify potential safety and efficacy trends
  • Excellent knowledge of ICH and FDA GCP Guidelines
  • Experience working in global regulatory and pharmacovigilance environments preferred
  • Demonstrated ability to think analytically and strategically, work independently, and solve problems
  • Highly motivated, accountable, self-directed, and able to execute with attention to detail
  • Excellent communication and interpersonal relationship skills including negotiating and relationship management skills across multiple functions and with external vendors
  • Skilled at prioritizing tasks to deliver on deadlines in a highly collaborative and collegial work style
  • Patient-focused with a deep commitment to understanding patient needs
  • Gene therapy and/or rare disease experience in biotech company preferred
  • Enjoy being part of a growing team and fast-paced environment 

$176,000 - $193,000 a year

Base salary dependent on qualifications and overall experience.

About Lexeo

Lexeo Therapeutics is a New York City-based, clinical stage genetic medicine company dedicated to transforming healthcare by applying pioneering science to fundamentally change how genetically defined cardiovascular diseases and APOE4-associated Alzheimer’s disease are treated. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of clinical and preclinical programs.  Lexeo successfully completed a $112M IPO in November 2023 and in early March 2024 announced a PIPE raising an additional $95M, extending the Company’s runway into 2027.

Our work culture for most roles is a hybrid model with days in the New York City office and days working from home.  We welcome applications from candidates located across the Northeast and Mid-Atlantic. Remote work can be considered for exceptional candidates.

Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
Apply now

Director/Senior Director, Clinical Statistician

  • Hybrid / Full time
  • New York, New York, US
The Director/Senior Director, Clinical Statistician will lead and manage biostatistical activities across a complex portfolio of gene therapy studies and other projects. You will collaborate with cross-functional partners to meet clinical development project deliverables and timelines. This may include, but is not limited to, serving as the statistics lead on project teams, providing statistical input on clinical development plans, clinical trial design and clinical study endpoints, calculating sample size, authoring statistical analysis plans, ensuring analyses are completed appropriately and accurately, and that study results and conclusions in scientific publications/presentations and regulatory filings are scientifically sound and supported by the statistical analyses.

You will be responsible for the analysis of interim and final data sets and will oversee data and programming deliverables accountable by the CRO.

Lexeo has a hybrid work culture but is open to remote candidates within the US for this role.

Primary Responsibilities

  • Responsible for biostatistical activities for a complex portfolio of clinical studies for gene therapy programs
  • Ensures timely and appropriate gathering, organization, and analysis of different data sources to support clinical trial design and clinical study endpoints
  • Lead statistical input to clinical trial design and protocol development
  • Author statistical analysis plans in conjunction with the clinical team
  • Align the requirements for data reporting, tables, listings, and figures required for interim and final reports, including topline reports and final clinical study reports
  • Oversees and directs completion of all technical and operational statistical activities Directs internal and external teams in the definition, execution, and completion of statistical activities for programs
  • Contribute to clinical development planning for the portfolio
  • Provide timely and appropriate advice to internal and external partners on statistical analysis strategies, reliability of measurements, and identifiability of models
  • Reviews and approves biostatistical input into clinical development documentation, scientific publications and presentations, and regulatory documentation, ensuring accuracy of the data, that data are presented clearly, and the conclusions drawn are scientifically sound and supported by the statistical analyses
  • Represent statistics function with senior management and other external partners, including regulatory agencies
  • Typically takes a lead in special projects that can benefit the portfolio, such as new methodologies, processes, technology, and other tools, and may also lead the development and/or implementation of SOPs and related documentation
  • Adheres to regulatory requirements of study conduct, statistical analysis principles, industry standards, and Lexeo’s SOPs

Required Skills & Qualifications

  • PhD in biostatistics or related discipline with 8+ years’ relevant experience in statistical analysis of biomedical data using SAS or equivalent software in the biopharma industry or a related environment
  • MS in biostatistics or related discipline with 10+ years’ relevant experience in statistical analysis of biomedical data using SAS or equivalent software
  • Extensive biomedical statistical analysis experience and experience working with relevant software
  • Experience developing software and other tools to support statistical analysis of biomedical or related data. Strong proficiencies in software and other tools typically used by Biostatistics
  • Demonstrated excellence in complex project management and effectively managing multiple projects and priorities
  • Experience working with CROs for data and programming deliverables
  • Expert level of knowledge of biostatistics, as evidenced by independence in assuming responsibilities for complex Phase 1-3 gene therapy projects
  • Advanced knowledge of biostatistics best practices and tools and has shown the ability to apply this to improve overall results
  • Demonstrates strategic thinking in advising others on statistical requirements and opportunities to improve study or other project outcomes
  • In-depth understanding of the cross-functional roles and responsibilities involved in drug development
  • Knowledge of FDA and EMA regulations, ICH guidelines, GCP, and familiarity with standard clinical procedures
  • Strong communication and organizational skills. Demonstrable abilities to effectively communicate project direction and status to varying organizational levels, including leadership teams, executives, and steering committees
  • When needed, the ability to travel
  • Ability to handle multiple development programs simultaneously
  • Excellent teamwork, organizational, interpersonal, conflict resolution and problem-solving skills
  • Excellent written and verbal communication skills demonstrated by ability to present clear instruction/direction
  • Analytical and problem-solving capabilities
  • Collaborative and collegial work style
  • Attention to detail and follow-up

$200,000 - $280,000 a year

Base salary dependent on qualifications and overall experience.

About Lexeo

Lexeo Therapeutics is a New York City-based, clinical stage genetic medicine company dedicated to transforming healthcare by applying pioneering science to fundamentally change how genetically defined cardiovascular diseases and APOE4-associated Alzheimer’s disease are treated. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of clinical and preclinical programs.  Lexeo successfully completed a $112M IPO in November 2023 and in early March 2024 announced a PIPE raising an additional $95M, extending the Company’s runway into 2027.

Our work culture for most roles is a hybrid model with days in the New York City office and days working from home.  We welcome applications from candidates located across the Northeast and Mid-Atlantic. Remote work can be considered for exceptional candidates.

Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
Apply now

Development Operations

Director of Outsourcing Management

  • Remote / Full time
  • New York, New York, US
The Director of Outsourcing Management (DOM) is a highly motivated, results-driven individual seeking a challenging leadership role. This position is responsible for evaluating, selecting, and collaborating with the team to effectively oversee vendors that provide critical services to Lexeo’s development team. The ideal candidate is a strategic thinker with excellent communication and organizational skills, along with a strong understanding of outsourcing processes and regulations.

This role is open to remote candidates within the United States. Some travel is required.

Primary Responsibilities

  • Oversee and manage all complex outsourced activities for Lexeo’s Clinical Development Organization. 
  • Develop and implement strategies and processes that optimize the efficiency and effectiveness of Lexeo’s outsourcing needs. 
  • Ensure compliance with all relevant regulations and guidelines related to outsourcing. 
  • Communicate effectively with internal stakeholders and external vendors to ensure smooth and successful outsourcing operations. 
  • Monitor and evaluate vendor performance to ensure quality and timely delivery of services. 
  • Develop, analyze, and report on key performance indicators to senior management. 
  • Work closely with cross-functional teams to identify areas for improvement and implement solutions. 
  • Develop and maintain strong relationships with vendors to foster a collaborative and productive working environment. 
  • Keep up to date with industry trends and best practices in outsourcing management. 
  • Develop and manage budgets for outsourcing activities. 
  • Identify and mitigate potential risks associated with outsourcing activities. 
  • Collaborate with legal and compliance teams to ensure all contracts and agreements with vendors are aligned with company policies and procedures. 
  • Drive continuous improvement and innovation in outsourcing processes to enhance overall company performance. 
  • Represent the company in vendor meetings, negotiations, and other relevant forums.

Required Skills & Qualifications

  • Bachelor’s degree required; advanced degree is strongly preferred (Scientific, JD, MBA)
  • 10-12 years combined experience in pharmaceutical research, legal, strategy, or financial analysis required. Pharmaceutical, licensing, CRO, or legal experience preferred. 
  • Strong knowledge of drug development, project management, quality assurance, clinical and non-clinical research, legal, and regulatory functions. 
  • In-depth understanding of outsourcing processes, legal, QA, and finance policies and procedures within a drug development setting.  
  • Proven ability to leverage resources in a global environment without direct reporting responsibility/authority. Demonstrated leadership skills with a very broad business orientation. Responsible to teams but with no direct reporting responsibility/authority for those functional areas. 
  • Proven project management skills with a track record of success in managing broad-scope projects involving cross-functional teamwork. 
  • Demonstrated strategic thinking and planning skills with strong analytical capabilities to evaluate scientific and financial data, identify key issues, and establish priorities. 
  • Proven negotiation skills and experience managing contracts and vendor relationships. 
  • Excellent written and verbal communication skills, with experience in preparing and presenting key information to senior-level management. 
  • Ability to build and sustain effective internal and external partnerships. Strong relationship management and influencing skills are required with a high degree of customer focus. 
  • Problem-solving abilities at strategic and operational levels to address contract issues, supplier management and performance, cross-functional challenges, and resolution between functional areas and external suppliers.  
  • Advanced analytical skills that lead to value generation, contract optimization, and risk identification. 

$185,000 - $241,000 a year

Base salary dependent upon qualifications and overall experience.

About Lexeo

Lexeo Therapeutics is a New York City-based, clinical stage genetic medicine company dedicated to transforming healthcare by applying pioneering science to fundamentally change how genetically defined cardiovascular diseases and APOE4-associated Alzheimer’s disease are treated. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of clinical and preclinical programs.  Lexeo successfully completed a $112M IPO in November 2023 and in early March 2024 announced a PIPE raising an additional $95M, extending the Company’s runway into 2027.

Our work culture for most roles is a hybrid model with days in the New York City office and days working from home.  We welcome applications from candidates located across the Northeast and Mid-Atlantic. Remote work can be considered for exceptional candidates.

Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
Apply now